The emerging mechanisms of isoform-specific PI3K signalling

被引：1399

作者：

Vanhaesebroeck, Bart ^{[1
]}

Guillermet-Guibert, Julie ^{[1
]}

Graupera, Mariona ^{[1
]}

Bilanges, Benoit ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Cell Signalling, Inst Canc, London EC1M 6BQ, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 05期

基金：

英国医学研究理事会;

关键词：

II PHOSPHOINOSITIDE 3-KINASE; CANCER-SPECIFIC MUTATIONS; GROWTH-FACTOR RECEPTOR; LIPID KINASE-ACTIVITY; PHOSPHATIDYLINOSITOL; 3-KINASE; DISTINCT ROLES; CELL-MIGRATION; CAENORHABDITIS-ELEGANS; PHAGOSOME MATURATION; REGULATES AUTOPHAGY;

D O I：

10.1038/nrm2882

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological functions. A further level of complexity derives from the existence of eight PI3K isoforms, which are divided into class I, class II and class III PI3Ks. PI3K signalling has been implicated in metabolic control, immunity, angiogenesis and cardiovascular homeostasis, and is one of the most frequently deregulated pathways in cancer. PI3K inhibitors have recently entered clinical trials in oncology. A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.

引用

页码：329 / 341

页数：13

共 175 条

[81] Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
Kang, S
Denley, A
Vanhaesebroeck, B
Vogt, PK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) : 1289 - 1294
[82] Mutated PI 3-kinases - Cancer targets on a silver platter
Kang, S
Bader, AG
Zhao, L
Vogt, PK
[J]. CELL CYCLE, 2005, 4 (04) : 578 - 581
[83] Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
Kang, S
Song, H
Kang, J
Kang, H
Lee, D
Lee, Y
Park, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 329 (01) : 6 - 10
[84] Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanism
Katso, Roy M.
Pardo, Olivier E.
Palamidessi, Andrea
Franz, Clemens M.
Marinov, Marin
De Laurentiis, Angela
Downward, Julian
Scita, Giorgio
Ridley, Anne J.
Waterfleld, Michael D.
Arcaro, Alexandre
[J]. MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (09) : 3729 - 3744
[85] Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
Kihara, A
Noda, T
Ishihara, N
Ohsumi, Y
[J]. JOURNAL OF CELL BIOLOGY, 2001, 152 (03) : 519 - 530
[86] A pathway for phagosome maturation during engulfment of apoptotic cells
Kinchen, Jason M.
Doukoumetzidis, Kimon
Almendinger, Johann
Stergiou, Lilli
Tosello-Trampont, Annie
Sifri, Costi D.
Hengartner, Michael O.
Ravichandran, Kodi S.
[J]. NATURE CELL BIOLOGY, 2008, 10 (05) : 556 - 566
[87] Knight ZA, 2006, CELL, V125, P733, DOI 10.1016/j.cell.2006.03.035
[88] Regulation of phosphoinositide 3-kinase expression in health and disease
Kok, Klaartje
Geering, Barbara
Vanhaesebroeck, Bart
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2009, 34 (03) : 115 - 127
[89] Autophagic cell death: the story of a misnomer
Kroemer, Guido
Levine, Beth
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (12) : 1004 - 1010
[90] Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt
Kubo, H
Hazeki, K
Takasuga, S
Hazeki, O
[J]. BIOCHEMICAL JOURNAL, 2005, 392 : 607 - 614

← 4 5 6 7 8 9 10 11 12 13 →