Cavity effects on the enantioselectivity of chiral amido[4]resorcinarene stereoisomers

被引：32

作者：

Botta, B

Subissati, D

Tafi, A

Delle Monache, G

Filippi, A

Speranza, M

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Sostanze Biologicament, I-00185 Rome, Italy

[2] Univ Siena, Dipartimento Farm Chim Tecnol, I-53100 Siena, Italy

[3] Univ Cattolica Sacro Cuore, Ist Chim Riconoscimento Mol, I-00168 Rome, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 36期

关键词：

enantioselectivity; enzyme models; host-guest systems; kinetics; macrocycles;

D O I：

10.1002/anie.200460663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dramatic effects of the size and hydrophilic/hydrophobic properties of cavities on the intrinsic reaction kinetics and dynamics is shown by the gas-phase reaction of (R)-(-)-2-butylamine and complexes of stereoisomeric amido[4]resorcinarene hosts with aromatic amino acids. The graph shows the kinetic plots of the base-induced loss of L-Phe (green), L-Tyr (red), and L-dopa (blue).

引用

页码：4767 / 4770

页数：4

共 13 条

[11] Enantioselectivity in gas-phase ion-molecule reactions [J].