The regulation of IL-10 production by immune cells

被引：2345

作者：

Saraiva, Margarida ^{[2
]}

O'Garra, Anne ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

CD4(+) T-CELLS; TOLL-LIKE RECEPTOR-2; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; INHIBITS CYTOKINE PRODUCTION; ACTIVATED PROTEIN-KINASES; TRANS-RETINOIC ACID; FACTOR C-MAF; TRANSCRIPTION FACTOR; GENE-EXPRESSION;

D O I：

10.1038/nri2711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.

引用

页码：170 / 181

页数：12

共 169 条

[1] ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis [J].

Agrawal, Anshu ;

Dillon, Stephanie ;

Denning, Timothy L. ;

Pulendran, Bali .

JOURNAL OF IMMUNOLOGY, 2006, 176 (10) :5788-5796

[2] Cutting edge: Different toll-like receptor agonists instruct dendritic cells to induce distinct th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-fos [J].

Agrawal, S ;

Agrawal, A ;

Doughty, B ;

Gerwitz, A ;

Blenis, J ;

Van Dyke, T ;

Pulendran, B .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :4984-4989

[3] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[4]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[5] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[6] The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [J].

Ananieva, Olga ;

Darragh, Joanne ;

Johansen, Claus ;

Carr, Julia M. ;

McIlrath, Joanne ;

Park, Jin Mo ;

Wingate, Andrew ;

Monk, Claire E. ;

Toth, Rachel ;

Santos, Susana G. ;

Iversen, Lars ;

Arthur, J. Simon C. .

NATURE IMMUNOLOGY, 2008, 9 (09) :1028-1036

[7] CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis [J].

Anderson, Charles F. ;

Oukka, Mohammed ;

Kuchroo, Vijay J. ;

Sacks, David .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :285-297

[8] Post-transcriptional control of cytokine production [J].

Anderson, Paul .

NATURE IMMUNOLOGY, 2008, 9 (04) :353-359

[9] Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice:: Control by CD4+ regulatory T cells and IL-10 [J].

Asseman, C ;

Read, S ;

Powrie, F .

JOURNAL OF IMMUNOLOGY, 2003, 171 (02) :971-978

[10] Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells [J].

Banerjee, A ;

Gugasyan, R ;

McMahon, M ;

Gerondakis, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3274-3279

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