The regulation of IL-10 production by immune cells

被引：2425

作者：

Saraiva, Margarida ^{[2
]}

O'Garra, Anne ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

CD4(+) T-CELLS; TOLL-LIKE RECEPTOR-2; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; INHIBITS CYTOKINE PRODUCTION; ACTIVATED PROTEIN-KINASES; TRANS-RETINOIC ACID; FACTOR C-MAF; TRANSCRIPTION FACTOR; GENE-EXPRESSION;

D O I：

10.1038/nri2711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.

引用

页码：170 / 181

页数：12

共 169 条

[11] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[12] CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production [J].

Barthlott, T ;

Moncrieffe, H ;

Veldhoen, M ;

Atkins, CJ ;

Christensen, J ;

O'Garra, A ;

Stockinger, B .

INTERNATIONAL IMMUNOLOGY, 2005, 17 (03) :279-288

[13] Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells [J].

Batten, Marcel ;

Kljavin, Noelyn M. ;

Li, Ji ;

Walter, Michael J. ;

de Sauvage, Frederic J. ;

Ghilardi, Nico .

JOURNAL OF IMMUNOLOGY, 2008, 180 (05) :2752-2756

[14] Functions of NF-κB1 and NF-κB2 in immune cell biology [J].

Beinke, S ;

Ley, SC .

BIOCHEMICAL JOURNAL, 2004, 382 :393-409

[15] Regulatory T cells and infection: a dangerous necessity [J].

Belkaid, Yasmine .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (11) :875-888

[16] All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation [J].

Benson, Micah J. ;

Pino-Lagos, Karina ;

Rosemblatt, Mario ;

Noelle, Randolph J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1765-1774

[17] Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals [J].

Boonstra, Andre ;

Rajsbaum, Ricardo ;

Holman, Mary ;

Marques, Rute ;

Asselin-Paturel, Carine ;

Pereira, Joao Pedro ;

Bates, Elizabeth E. M. ;

Akira, Shizuo ;

Vieira, Paulo ;

Liu, Yong-Jun ;

Trinchieri, Giorgio ;

O'Garra, Anne .

JOURNAL OF IMMUNOLOGY, 2006, 177 (11) :7551-7558

[18] cAMP-induced interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation [J].

Brenner, S ;

Prösch, S ;

Schenke-Layland, K ;

Riese, U ;

Gausmann, U ;

Platzer, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :5597-5604

[19] A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages [J].

Brightbill, HD ;

Plevy, SE ;

Modlin, RL ;

Smale, ST .

JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1940-1951

[20] Interleukin-10 determines viral clearance or persistence in vivo [J].

Brooks, David G. ;

Trifilo, Matthew J. ;

Edelmann, Kurt H. ;

Teyton, Luc ;

McGavern, Dorian B. ;

Oldstone, Michael B. A. .

NATURE MEDICINE, 2006, 12 (11) :1301-1309

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