Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya.

被引：164

作者：

Hanke, T ^{[1
]}

McMichael, AJ ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DS, England

来源：

NATURE MEDICINE | 2000年 / 6卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/79626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using recent advances in biological and medical sciences, a new candidate human immunodeficiency virus (HIV) vaccine has been developed and tailor-designed for a phase III clinical trial in Kenya. It has two components, DNA and MVA (an attenuated poxvirus), used in a prime-boost vaccination protocol. Both of these vaccine vehicles express a common 'chimeric' protein derived from small parts of the HIV genome. The vaccine focuses on the induction of cell-mediated immune responses.

引用

页码：951 / 955

页数：5

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