An allylic isoprenoid C-5 nucleophile for the synthesis of forskolin

被引:13
作者
Behnke, D [1 ]
Hamm, S [1 ]
Hennig, L [1 ]
Welzel, P [1 ]
机构
[1] UNIV LEIPZIG,INST ORGAN CHEM,D-04103 LEIPZIG,GERMANY
关键词
D O I
10.1016/S0040-4039(97)01662-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
InCl3-mediated coupling of delta-alkoxy allylic stannane 9b with aldehydes has been shown to give the a-coupling products in high yield, probably via two S-E' processes. Most specifically, drimenal (rac-1) has been converted into labdane derivative 17 which is considered to be an important intermediate on the way to forskolin. (C) 1997 Published by Elsevier Science Ltd.
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页码:7059 / 7062
页数:4
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