Vesparioside from the marine sponge Spheciospongia vesparia, the first diglycosylceramide with a pentose sugar residue

被引：13

作者：

Costantino, V ^{[1
]}

Fattorusso, E ^{[1
]}

Imperatore, C ^{[1
]}

Mangoni, A ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 02期

关键词：

glycolipids; natural products; sphingolipids; structure elucidation; pentose;

D O I：

10.1002/ejoc.200400543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The marine sponge Spheciospongia vesparia produces ves-parioside (1a), a diglycosylated glycosphingolipid which is the first example of a natural diglycosylceramide with a pentose sugar residue. The structure of vesparioside was mostly determined by extensive spectroscopic analysis but determination of the nature of the alkyl chains and elucidation of the absolute stereochemistry of the sugars and of the ceramide required chemical degradation. In this respect, an improved and simplified procedure for the microscale chemical degradation of glycosphingolipids was employed here for the first time. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：368 / 373

页数：6

共 8 条

[1]

Borbone N, 2001, EUR J ORG CHEM, V2001, P4651

[2] Glycolipids from sponges.: 13.: Clarhamnoside, the first rhamnosylated α-galactosylceramide from Agelas clathrodes.: Improving spectral strategies for glycoconjugate structure determination [J].