Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro

被引：55

作者：

Nagase, H ^{[1
]}

Sasaki, K ^{[1
]}

Kito, H ^{[1
]}

Haga, A ^{[1
]}

Sato, T ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Dept Publ Hlth, Gifu 502, Japan

来源：

PLANTA MEDICA | 1998年 / 64卷 / 03期

关键词：

delphinidin; Solanum melongena; Solanaceae; invasion; inhibition of matrix metalloproteinase; HT-1080; cells;

D O I：

10.1055/s-2006-957412

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We investigated the inhibitory effect of eggplant (Solanum melongena var, marunasu) extract on human fibrosarcoma HT-1080 cell invasion of reconstituted basement membrane [Matrigel (MG)]. We found that the effective component of the plant extract was delphinidin, a flavonoid pigment contained in the peel. The extract and delphinidin did not affect tumor cell adhesion to MG or haptotactic migration to MC. HT-1080 secretes matrix metalloproteinase(MMP)-2 and MMP-9, which degrade extracellular matrix as part of the invasive process. Delphinidin slightly inhibited the activity of MMPs, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.

引用

页码：216 / 219

页数：4

共 26 条

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