EFFECTS OF THE PLANT FLAVONOID BAOHUOSIDE-1 ON CANCER-CELLS INVITRO

被引：13

作者：

LI, SY

TEH, BS

SEOW, WK

LI, F

THONG, YH

机构：

[1] UNIV QUEENSLAND,MATER CHILDRENS HOSP,DEPT CHILD HLTH,IMMUNOBIOL LAB,BRISBANE,QLD 4101,AUSTRALIA

[2] CHINESE ACAD MED SCI,INST MED BIOTECHNOL,BEIJING,PEOPLES R CHINA

[3] CHINESE ACAD MED SCI,INST MED PLANT DEV,BEIJING,PEOPLES R CHINA

来源：

CANCER LETTERS | 1990年 / 53卷 / 2-3期

关键词：

anti-tumor activity; Berberidaceae family; Epimedium davidii; plant flavanoids;

D O I：

10.1016/0304-3835(90)90211-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The novel plant flavonoid 3,5,7,-trihydroxy-4′-methoxyl-8′-prenylflavone-3-O-α-L-rhamnopranoxide (designated baohuoside-1) was shown to have cytotoxic and cytostatic effects on 6 cancer cell-lines, by means of microscopy, 51Cr-release and growth inhibition. The IC50 on the cells tested ranged from 2.8 to 7.5 μg/ml. At tumouricidal concentrations, inhibition of DNA and RNA synthesis, but not protein synthesis was observed. © 1990.

引用

页码：175 / 181

页数：7

共 17 条

[1] INCREASED YIELDS OF IL-2 IN MEDIA CONDITIONED BY MLA-144 CELLS
ASPINALL, R
OGORMAN, A
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 101 (01) : 79 - 84
[2] CHANG HM, 1986, PHARM APPLICATIONS C
[3] 2 PHARMACOLOGICAL TRADITIONS - NOTES FROM EXPERIENCE
CHEN, KK
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1981, 21 : 1 - 6
[4] CONTINUOUS GROWTH AND DIFFERENTIATION OF HUMAN MYELOID LEUKEMIC-CELLS IN SUSPENSION CULTURE
COLLINS, SJ
GALLO, RC
GALLAGHER, RE
[J]. NATURE, 1977, 270 (5635) : 347 - 349
[5] FARNSWORTH N, 1988, CURR CONTENTS, V31, P9
[6] Harbone J. B., 1982, FLAVONOIDS ADV RES
[7] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA
KLAYMAN, DL
[J]. SCIENCE, 1985, 228 (4703) : 1049 - 1055
[8] KONEMAN EW, 1988, COLOR ATLAS TXB DIAG, P723
[9] C-13 NMR-STUDIES OF FLAVONOIDS .3. NATURALLY OCCURRING FLAVONOID GLYCOSIDES AND THEIR ACYLATED DERIVATIVES
MARKHAM, KR
TERNAI, B
STANLEY, R
GEIGER, H
MABRY, TJ
[J]. TETRAHEDRON, 1978, 34 (09) : 1389 - 1397
[10] EFFECTS OF ADRIAMYCIN AND ETOPOSIDE ON THE REPLICATION OF ADENOVIRUS-5 IN SENSITIVE AND RESISTANT HUMAN-TUMOR CELLS
PARSONS, PG
LEAN, J
KHOO, SK
LARK, J
[J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (01) : 31 - 37

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