Comparative enantiocontrol with allyl phenyldiazoacetates in asymmetric catalytic intramolecular cyclopropanation

被引：13

作者：

Doyle, MP ^{[1
]}

Hu, WH ^{[1
]}

Weathers, TM ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

CHIRALITY | 2003年 / 15卷 / 04期

关键词：

chiral dirhodium(II) carboxamidates; metal carbene reactions; azetidinone ligands; steric control;

D O I：

10.1002/chir.10219

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dirhodium(II) azetidinone-carboxylates are effective asymmetric catalysts for diazo, decomposition of allyl diazoacetates and their subsequent intramolecular cyclopropanations. The effect of alkene substituents on enantiocontrol has been examined and modest selectivities have been achieved. Steric influences from substituents on the diazo carbon are seen to diminish enantioselectivities.

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收藏

页码：369 / 373

页数：5

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