Pathogenesis of bacterial meningitis: From bacteraemia to neuronal injury

被引:320
作者
Kim, KS [1 ]
机构
[1] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA
关键词
D O I
10.1038/nrn1103
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Bacterial meningitis is an important cause of mortality and morbidity despite advances in antimicrobial therapy. A key factor that contributes to the high prevalence of this condition is the incomplete understanding of its pathogenesis. Most cases of bacterial meningitis develop as a result of haematogenous spread, but it is unclear how circulating bacteria cross the blood-brain barrier, and how bacterial entry into the central nervous system results in inflammation and in complications such as pleocytosis, blood-brain barrier disruption and neuronal injury. Recent studies have shed light on the pathogenic mechanisms of bacterial translocation across the blood-brain barrier and the meningitis-associated complications. I propose that bacterial translocation, a key step for the development of meningitis, is the result of specific bacteria-host interactions, and that its complications are the result of multiple host responses to the invading microorganism.
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页码:376 / 385
页数:10
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