Transthyretin and transferrin in hemangioblastoma stromal cells

被引:15
作者
Bleistein, M
Geiger, K
Franz, K
Stoldt, P
Schlote, W
机构
[1] Univ Marburg, Abt Neuropathol, Dept Neuropathol, D-35043 Marburg, Germany
[2] Goethe Univ Frankfurt, Dept Neuropathol, D-6000 Frankfurt, Germany
[3] Goethe Univ Frankfurt, Dept Neurosurg, D-6000 Frankfurt, Germany
关键词
hemangioblastoma; stromal cells; transthyretin; transferrin; collagen IV; immunohistochemistry;
D O I
10.1016/S0344-0338(00)80119-3
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Hemangioblastoma, a rare benign tumor of the CNS, consists of two main components: capillaries and stromal cells. Despite many efforts, the histogenesis of stromal cells is still unknown. We took a new approach to clarify the origin of stromal cells using immunohistochemical methods. Paraffin-embedded tissue of 24 surgically removed hemangioblastomas of the CNS was examined with antibodies against transthyretin, transferrin, vimentin, NSE, protein S-100, CK 8, KL-1, EMA, CD34, factor VIII rAg, and collagen IV. Stromal cells showed a positive reaction with anti-transthyretin in 12 of 24 hemangioblastomas, a positive reaction with anti-transferrrin, to a different extent, in 13 of 24 cases, and many stromal cells expressed basal membrane collagen IV on the cell surface in 19 of 24 cases. The expression of transthyretin and transferrin in stromal cells of hemangioblastomas is reported for the first time, thus providing an antigenic profile of hemangioblastoma stromal cells that is very similar to that of immature choroid plexus epithelium. These findings support the notion that hemangioblastoma stromal cells may originate from the embryonal plexus epithelium. We discuss our results with special regard to stromal cell histogenesis, including a review of the literature.
引用
收藏
页码:675 / 681
页数:7
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