An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine

被引：42

作者：

Fuwa, Haruhiko ^{[1
]}

Sasaki, Makoto ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Lab Biostruct Chem, Sendai, Miyagi 9818555, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 12期

关键词：

6-MEMBERED HETEROCYCLIC RINGS; INTRAMOLECULAR HECK REACTION; ARYL RADICAL CYCLIZATION; PALLADIUM(0)-CATALYZED SILYLATION; ASYMMETRIC-SYNTHESIS; SIMPLE ROUTE; SI-H; REDUCTION; ISOINDOLOISOQUINOLINE; HALIDES;

D O I：

10.1039/b706087d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of enol ethers and enecarbamates has been developed based on catalytic hydrosilane reduction of alpha-phosphonoxy enol ethers and alpha-phosphonoxy enecarbamates. This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine.

引用

页码：1849 / 1853

页数：5

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