A-type lamins: Guardians of the soma?

被引：170

作者：

Hutchison, CJ

Worman, HJ

机构：

[1] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 4EB, England

[2] Columbia Univ, Coll Phys & Surg, New York, NY 10032 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 11期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

D O I：

10.1038/ncb1104-1062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies-inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of transcription factors required for the differentiation of adult stem cells. Thus, the degenerative nature of laminopathies is explained because these lamins are essential for maintenance of somatic tissues in adulthood.

引用

收藏

页码：1062 / 1067

页数：6

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