Are Host Genetics the Predominant Determinant of Persistent Nasal Staphylococcus aureus Carriage in Humans?

被引:121
作者
Ruimy, Raymond [1 ,2 ]
Angebault, Cecile [2 ]
Djossou, Felix [7 ]
Dupont, Claire [2 ]
Epelboin, Loic [2 ]
Jarraud, Sophie [4 ,5 ]
Armand Lefevre, Laurence [2 ]
Bes, Michele [4 ,5 ]
Lixandru, Brandusa Elena [2 ]
Bertine, Melanie [2 ]
El Miniai, Assiya [2 ]
Renard, Magaly
Bettinger, Regis Marc
Lescat, Mathilde [3 ]
Clermont, Olivier [3 ]
Peroz, Gilles [8 ]
Lina, Gerard [4 ,5 ]
Tavakol, Mehri [9 ]
Vandenesch, Francois [4 ,5 ]
van Belkum, Alex [9 ]
Rousset, Francois [6 ]
Andremont, Antoine [2 ]
机构
[1] Hop Bichat Claude Bernard, AP HP, Bacteriol Lab, CNR, F-75018 Paris, France
[2] Univ Paris Diderot, EA3964, Paris, France
[3] INSERM, U722, Paris, France
[4] INSERM, U851, F-69008 Lyon, France
[5] Univ Lyon 1, Ctr Natl Reference Staphylocoques, Fac Laennec, F-69365 Lyon, France
[6] Univ Montpellier 2, CNRS, UMR 5554, Inst Sci Evolut, Montpellier, France
[7] Ctr Hosp Cayenne Andree Rosemon, Cayenne, French Guiana
[8] CNRS Guyane, UPS N 2561, Cayenne, French Guiana
[9] Erasmus MC, Univ Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
关键词
FRENCH-GUIANA; UNITED-STATES; RISK-FACTORS; COLONIZATION; RESISTANCE; POLYMORPHISMS; POPULATIONS; PREVALENCE; EMERGENCE; VIRULENCE;
D O I
10.1086/655901
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Staphylococcus aureus nasal carriage is influenced by multifactorial interactions which are difficult to study in open populations. Therefore, we concomitantly assessed the epidemiological, microbiological, and human-genetic carriage-related factors in a nearly closed population. Methods. In 2006 and 2008, we collected nasal S. aureus strains, human DNA, and epidemiological data from 154 adult Wayampi Amerindians living in an isolated village in the Amazonian forest. The genetics of the strains (multilocus sequence type, spa type, and toxin-content type), epidemiological risk factors, antibiotic exposure, and allelic polymorphism of human genes putatively involved in carriage of the persistent carriers were compared with those of other volunteers. Results. Overall carriage prevalence was 41.7% in 2006 and 57.8% in 2008, but the overall prevalence of persistent carriage was only 26%. The rare and phylogenetically distant multilocus sequence type ST1223 was present in 18.5% of the carriers in 2006 and 34.8% in 2008. No epidemiological factors or antibiotic exposure were significantly associated with persistent carriage, but single nucleotide polymorphism distribution in C-reactive proteins C2042T and C1184T and interleukin-4 C524T genes was significantly associated (P=.02, by global test). Conclusion. Host genetic factors appeared to be the predominant determinant for S. aureus persistent nasal carriage in humans.
引用
收藏
页码:924 / 934
页数:11
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