Metabolic fuel selection: the importance of being flexible

被引：8

作者：

Bickel, PE

机构：

[1] Univ Washington, Sch Med, Dept Med, St Louis, MO 63105 USA

[2] Univ Washington, Sch Med, Dept Cell Biol & Physiol, Div Endocrinol Metab & Lipid Res, St Louis, MO 63105 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 11期

关键词：

D O I：

10.1172/JCI200423745

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Studies in genetically engineered mice have shown the importance of crosstalk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported (see the related article beginning on page 1666). These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lipid synthesis as well as by increasing lipid utilization in peripheral tissues. These findings are relevant to humans with type 2 diabetes, in whom a key feature is diminished peripheral glucose disposal.

引用

收藏

页码：1547 / 1549

页数：3

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