Lab-on-a-chip for drug development

被引:380
作者
Weigl, BH
Bardell, RL
Cabrera, CR
机构
[1] Micron Inc, Redmond, WA 98052 USA
[2] Univ Washington, Seattle, WA 98095 USA
[3] Lincoln Lab, Lexington, MA 02420 USA
关键词
microfluidic; lab-on-a-chip; MicroTAS; electrokinetic;
D O I
10.1016/S0169-409X(02)00223-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Significant advances have been made in the development of micro-scale technologies for biomedical and drug discovery applications. The first generation of microfluidics-based analytical devices have been designed and are already functional. Microfluidic devices offer unique advantages in sample handling, reagent mixing, separation, and detection. We introduce and review microfluidic concepts, microconstruction techniques, and methods such as flow-injection analysis, electrokinesis, and cell manipulation. Advances in micro-device technology for proteomics, sample preconditioning, immunoassays, electrospray ionization mass spectrometry, and polymerase chain reaction are also reviewed. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:349 / 377
页数:29
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