Molecular and Cellular Dynamics at the Early Stages of Antigen Encounter: The B-Cell Immunological Synapse

被引：4

作者：

Carrasco, Yolanda R. ^{[1
]}

机构：

[1] CSIC, Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

IMMUNOLOGICAL SYNAPSE | 2010年 / 340卷

关键词：

FOLLICULAR DENDRITIC CELLS; MEMBRANE-BOUND ANTIGEN; IMMUNE-SYNAPSE; LYMPH-NODES; RECEPTOR MICROCLUSTERS; ANTIBODY-RESPONSES; SUBCAPSULAR SINUS; IN-VIVO; ACTIVATION; FOLLICLES;

D O I：

10.1007/978-3-642-03858-7_3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent development and application of sophisticated technology in the study of the initial stages of the B-cell immune response has lead to a tremendous revolution in the field. The use of real-time confocal microscopy, total interference reflection fluorescence (TIRF) microscopy and in vitro models has revealed the molecular details of the antigen recognition process by B cells. Moreover, experimental models that allow tracking of antigen in vivo in concert with multiphoton microscopy have provided critical information as to the how, where, and when naive B cells encounter antigen in vivo. This review focuses on the latest data regarding the early phase of the humoral immune response at molecular and cellular levels.

引用

页码：51 / 62

页数：12

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