Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a, member of the resistance/nodulation/division efflux pump family

被引：327

作者：

Shafer, WM ^{[1
]}

Qu, XD

Waring, AJ

Lehrer, RI

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[2] Vet Affairs Med Ctr, Labs Microbial Pathogenesis, Decatur, GA 30033 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

[5] King Drew Med Ctr, Dept Pediat, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 04期

关键词：

D O I：

10.1073/pnas.95.4.1829

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have previously described the antibacterial capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-1 and other structurally unrelated antibacterial peptides, including a peptide (LL-37) that is expressed constitutively by human granulocytes and testis and inducibly by keratinocytes, is modulated by an energy-dependent efflux system termed mtr. These results indicate that such efflux systems may enable mucosal pathogens like gonococci to resist endogenous antimicrobial peptides that are thought to act during infection.

引用

页码：1829 / 1833

页数：5

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