Modelling of the blood-brain barrier in drug discovery and development

被引：481

作者：

Cecchelli, Romeo ^{[1
]}

Berezowski, Vincent

Lundquist, Stefan

Culot, Maxime

Renftel, Mila

Dehouck, Marie-Pierre

Fenart, Laurence

机构：

[1] Univ Artois, Fac Jean Perrin, Lab Physiopathol Barriere Hemato Encephal, EA 2465,IMPRTIFR 114, F-62307 Lens, France

[2] AstraZeneca R&D Sodertalje, Dept Drug Metab & Pharmacokinet, S-15185 Sodertalje, Sweden

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 08期

关键词：

D O I：

10.1038/nrd2368

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The market for neuropharmaceuticals is potentially one of the largest sectors of the global pharmaceutical market owing to the increase in average life expectancy and the fact that many neurological disorders have been largely refractory to pharmacotherapy. The brain is a delicate organ that can efficiently protect itself from harmful compounds and precisely regulate its microenvironment. Unfortunately, the same mechanisms can also prove to be formidable hurdles in drug development. An improved understanding of the regulatory interfaces that exist between blood and brain may provide novel and more effective strategies to treat neurological disorders.

引用

页码：650 / 661

页数：12

共 125 条

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