Adaptation of core mechanisms to generate cell polarity

被引:546
作者
Nelson, WJ [1 ]
机构
[1] Stanford Univ, Beckman Ctr Mol & Genet Med, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
关键词
D O I
10.1038/nature01602
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of multi-cell organisms such as epithelia in worms, flies and mammals. This diversity raises several questions: do different cell types use different mechanisms to generate polarity, how is polarity signalled, how do cells react to that signal, and how is structural polarity translated into specialized functions? Analysis of evolutionarily diverse cell types reveals that cell-surface landmarks adapt core pathways for cytoskeleton assembly and protein transport to generate cell polarity.
引用
收藏
页码:766 / 774
页数:9
相关论文
共 101 条
  • [31] Rho-family GTPases in cadherin-mediated cell-cell adhesion
    Fukata, M
    Kaibuchi, K
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (12) : 887 - 897
  • [32] Assembly of epithelial tight is negatively regulated by junctions Par6
    Gao, L
    Joberty, G
    Macara, IG
    [J]. CURRENT BIOLOGY, 2002, 12 (03) : 221 - 225
  • [33] Role of bud6p and tea1p in the interaction between actin and microtubules for the establishment of cell polarity in fission yeast
    Glynn, JM
    Lustig, RJ
    Berlin, A
    Chang, F
    [J]. CURRENT BIOLOGY, 2001, 11 (11) : 836 - 845
  • [34] Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
    Grindstaff, KK
    Yeaman, C
    Anandasabapathy, N
    Hsu, SC
    Rodriguez-Boulan, E
    Scheller, RH
    Nelson, WJ
    [J]. CELL, 1998, 93 (05) : 731 - 740
  • [35] Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm
    Hunter, C
    Wieschaus, E
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 150 (02) : 391 - 401
  • [36] BASOLATERAL SORTING IN MDCK CELLS REQUIRES A DISTINCT CYTOPLASMIC DOMAIN DETERMINANT
    HUNZIKER, W
    HARTER, C
    MATTER, K
    MELLMAN, I
    [J]. CELL, 1991, 66 (05) : 907 - 920
  • [37] Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
    Hurd, TW
    Gao, L
    Roh, MH
    Macara, IG
    Margolis, B
    [J]. NATURE CELL BIOLOGY, 2003, 5 (02) : 137 - 142
  • [38] Bni1p and Bnr1p: Downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae
    Imamura, H
    Tanaka, K
    Hihara, T
    Umikawa, M
    Kamei, T
    Takahashi, K
    Sasaki, T
    Takai, Y
    [J]. EMBO JOURNAL, 1997, 16 (10) : 2745 - 2755
  • [39] An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
    Izumi, Y
    Hirose, T
    Tamai, Y
    Hirai, S
    Nagashima, Y
    Fujimoto, T
    Tabuse, Y
    Kemphues, KJ
    Ohno, S
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (01) : 95 - 106
  • [40] The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    Joberty, G
    Petersen, C
    Gao, L
    Macara, IG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (08) : 531 - 539