The IL-17 Family Cytokines in Immunity and Disease

被引：163

作者：

Pappu, Rajita ^{[1
]}

Ramirez-Carrozzi, Vladimir ^{[1
]}

Ota, Naruhisa ^{[1
]}

Ouyang, Wenjun ^{[1
]}

Hu, Yan ^{[1
]}

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2010年 / 30卷 / 02期

关键词：

IL-17; receptors; cytokines; host defense; autoimmunity; inflammation; COLLAGEN-INDUCED ARTHRITIS; RECEPTOR-LIKE PROTEIN; ROR-GAMMA-T; INTERLEUKIN-17; RECEPTOR; HOST-DEFENSE; RHEUMATOID-ARTHRITIS; CUTTING EDGE; TH17; CELLS; FUNCTIONAL-CHARACTERIZATION; PROINFLAMMATORY IL-17(+);

D O I：

10.1007/s10875-010-9369-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways. Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B-D, in inflammation remains to be determined. This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

引用

页码：185 / 195

页数：11

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