Pathogenesis and Management of Graft-versus-Host Disease

被引：129

作者：

Choi, Sung W. ^{[1
]}

Levine, John E. ^{[2
]}

Ferrara, James L. M. ^{[2
]}

机构：

[1] Univ Michigan, Dept Pediat, Blood & Marrow Transplant Program, Sch Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med & Pediat, Blood & Marrow Transplant Program, Sch Med, Ann Arbor, MI 48109 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2010年 / 30卷 / 01期

关键词：

Acute graft-versus-host disease; Chronic graft-versus-host disease; Hematopoietic cell transplantation; GVHD; ALLOGENEIC BONE-MARROW; STEM-CELL TRANSPLANTATION; UMBILICAL-CORD BLOOD; MINOR HISTOCOMPATIBILITY ANTIGENS; CONSENSUS DEVELOPMENT PROJECT; TREATMENT-RELATED MORTALITY; PLACEBO-CONTROLLED TRIAL; TOTAL-BODY IRRADIATION; REGULATORY T-CELLS; MYCOPHENOLATE-MOFETIL;

D O I：

10.1016/j.iac.2009.10.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allogeneic hematopoietic cell transplantation (HOT) is an important therapeutic option for various malignant and nonmalignant conditions. As allogeneic HCT continues to increase, greater attention is given to improvements in supportive care, infectious prophylaxis, immunosuppressive medications, and DNA-based tissue typing. However, graft versus host disease (GVHD) remains the most frequent and serious complication following allogeneic HOT and limits the broader application of this important therapy. Recent advances in the understanding of the pathogenesis of GVHD have led to new approaches to its management, including using it to preserve the graft versus leukemia effect following allogeneic transplant. This article reviews the important elements in the complex immunologic interactions involving cytokine networks, chemokine gradients, and the direct mediators of cellular cytotoxicity that cause clinical GVHD, and discusses the risk factors and strategies for management of GVHD.

引用

页码：75 / +

页数：29

共 155 条

[81] Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic cell transplantation [J].

Lin, M ;

Storer, B ;

Martin, PJ ;

Tseng, L ;

Gooley, T ;

Chen, P ;

Hansen, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (23) :2201-2210

[82] Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation:: synergism between IL-10 genotype of patient and IL-10 receptor β genotype of donor [J].

Lin, MT ;

Storer, B ;

Martin, PJ ;

Tseng, LH ;

Grogan, B ;

Chen, PJ ;

Zhao, LP ;

Hansen, JA .

BLOOD, 2005, 106 (12) :3995-4001

[83] HLA association with hematopoietic stem cell transplantation outcome: The number of mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 is strongly associated with overall survival [J].

Loiseau, Pascale ;

Busson, Marc ;

Balere, Marie-Lorraine ;

Dormoy, Anne ;

Mignon, Jean-Denis ;

Gagne, Katia ;

Gebuhrer, Lucette ;

Dubois, Valerie ;

Jollet, Isabelle ;

Bois, Monique ;

Perrier, Pascale ;

Masson, Dominique ;

Moine, Agnes ;

Absi, Lena ;

Reviron, Denis ;

Lepage, Virginia ;

Tamouza, Ryad ;

Toubert, Antoine ;

Marry, Evelyne ;

Chir, Zina ;

Jouet, Jean-Pierre ;

Blaise, Didier ;

Charron, Dominique ;

Raffoux, Colette .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (08) :965-974

[84] Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors [J].

MacMillan, Margaret L. ;

Weisdorf, Daniel J. ;

Brunstein, Claudio G. ;

Cao, Qing ;

DeFor, Todd E. ;

Verneris, Michael R. ;

Blazar, Bruce R. ;

Wagner, John E. .

BLOOD, 2009, 113 (11) :2410-2415

[85] Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: Comparison of grading systems [J].

MacMillan, ML ;

Weisdorf, DJ ;

Wagner, JE ;

DeFor, TE ;

Burns, LJ ;

Ramsay, NKC ;

Davies, SM ;

Blazar, BR .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (07) :387-394

[86] Critical role of host γδ T cells in experimental acute graft-versus-host disease [J].

Maeda, Y ;

Reddy, P ;

Lowler, KP ;

Liu, C ;

Bishop, DK ;

Ferrara, JLM .

BLOOD, 2005, 106 (02) :749-755

[87] T-CELL DEPLETION OF HLA-IDENTICAL TRANSPLANTS IN LEUKEMIA [J].

MARMONT, AM ;

HOROWITZ, MM ;

GALE, RP ;

SOBOCINSKI, K ;

ASH, RC ;

VANBEKKUM, DW ;

CHAMPLIN, RE ;

DICKE, KA ;

GOLDMAN, JM ;

GOOD, RA ;

HERZIG, RH ;

HONG, R ;

MASAOKA, T ;

RIMM, AA ;

RINGDEN, O ;

SPECK, B ;

WEINER, RS ;

BORTIN, MM .

BLOOD, 1991, 78 (08) :2120-2130

[88] Clinical and pharmacological risk factors for acute graft-versus-host disease after paediatric bone marrow transplantation from matched-sibling or unrelated donors [J].

Martin, P ;

Bleyzac, N ;

Souillet, G ;

Galambrun, C ;

Bertrand, Y ;

Maire, PH ;

Jelliffe, RW ;

Aulagner, G .

BONE MARROW TRANSPLANTATION, 2003, 32 (09) :881-887

[89] Evaluation of mycophenolate mofetil for initial treatment of chronic graft-versus-host disease [J].

Martin, Paul J. ;

Storer, Barry E. ;

Rowley, Scott D. ;

Flowers, Mary E. D. ;

Lee, Stephanie J. ;

Carpenter, Paul A. ;

Wingard, John R. ;

Shaughnessy, Paul J. ;

DeVetten, Marcel P. ;

Jagasia, Madan ;

Fay, Joseph W. ;

van Besien, Koen ;

Gupta, Vikas ;

Kitko, Carrie ;

Johnston, Laura J. ;

Maziarz, Richard T. ;

Arora, Mukta ;

Jacobson, Pamala A. ;

Weisdorf, Daniel .

BLOOD, 2009, 113 (21) :5074-5082

[90] A RETROSPECTIVE ANALYSIS OF THERAPY FOR ACUTE GRAFT-VERSUS-HOST DISEASE - INITIAL TREATMENT [J].

MARTIN, PJ ;

SCHOCH, G ;

FISHER, L ;

BYERS, V ;

ANASETTI, C ;

APPELBAUM, FR ;

BEATTY, PG ;

DONEY, K ;

MCDONALD, GB ;

SANDERS, JE ;

SULLIVAN, KM ;

STORB, R ;

THOMAS, ED ;

WITHERSPOON, RP ;

LOMEN, P ;

HANNIGAN, J ;

HANSEN, JA .

BLOOD, 1990, 76 (08) :1464-1472

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