DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk

被引:51
作者
Yu, HP
Zhang, XY
Wang, XL
Shi, LY
Li, YY
Li, F
Su, YH
Wang, YH
Lu, B
Sun, X
Lu, WH
Xu, SQ
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Environm Med, Wuhan 430030, Peoples R China
[2] Tumor Hosp Hubei, Dept Radiotherapy, Wuhan 430070, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Epidemiol & Hyg Stat, Wuhan 430030, Peoples R China
来源
CANCER DETECTION AND PREVENTION | 2004年 / 28卷 / 03期
基金
中国国家自然科学基金;
关键词
esophageal cancer; genetic polymorphism; susceptibility; XRCC1; gene; molecular epidemiology;
D O I
10.1016/j.cdp.2004.01.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg --> Trp) and codon 399 (Arg --> Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals. Although polymorphism at codon 194 was not associated with risk for ESCC, we found that the frequency of XRCC 1 399 Gln/Gln genotype in ESCC patients (14.1%) was significantly higher than that in normal controls (3.3%), and that XRCC 1399 Gln/Gln genotype was associated with an increased risk of ESCC (odds ratio (OR) = 5.15, 95% confiden,e interval (CI): 2.42-0.93). In addition, we found that the risk for smoker increased 4.2-fold than non-smokers in the 399 Gln/Gln genotype (OR = 4.20, 95% Cl: 2.37-7.44). These results suggest that XRCC 1399 Gln/Gln genotype may contribute to the risk of ESCC and modify risk associated with smoking. (C) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:194 / 199
页数:6
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