In the golden age of organocatalysis

被引:2623
作者
Dalko, PI
Moisan, L
机构
[1] ESPCI, CNRS, Rech Organ Lab, F-75231 Paris 05, France
[2] CEA Saclay, Serv Marquage Mol & Chim Bioorgan, F-91191 Gif Sur Yvette, France
关键词
asymmetric catalysis; chiral auxiliaries; organocatalysis; synthetic methods;
D O I
10.1002/anie.200400650
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The term "organocatalysis" describes the acceleration of chemical reactions through the addition of a substoichiometric quantity of an organic compound. The interest in this field has increased spectacularly in the last few years as result of both the novelty of the concept and, more importantly, the fact that the efficiency and selectivity of many organocatalytic reactions meet the standards of established organic reactions. Organocatalytic reactions are becoming powerful tools in the construction of complex molecular skeletons. The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose "Golden Age" has already dawned.
引用
收藏
页码:5138 / 5175
页数:38
相关论文
共 528 条
  • [41] Origins of opposite absolute stereloselectivities in proline-catalyzed direct Mannich and aldol reactions
    Bahmanyar, S
    Houk, KN
    [J]. ORGANIC LETTERS, 2003, 5 (08) : 1249 - 1251
  • [42] The origin of stereoselectivity in proline-catalyzed intramolecular aldol reactions
    Bahmanyar, S
    Houk, KN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (51) : 12911 - 12912
  • [43] Transition states of amine-catalyzed aldol reactions involving enamine intermediates: Theoretical studies of mechanism, reactivity, and stereoselectivity
    Bahmanyar, S
    Houk, KN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (45) : 11273 - 11283
  • [44] Chiral quinuclidine-based amine catalysts for the asymmetric one-pot, three-component aza-Baylis-Hillman reaction
    Balan, D
    Adolfsson, H
    [J]. TETRAHEDRON LETTERS, 2003, 44 (12) : 2521 - 2524
  • [45] Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram
    Barnes, DM
    Ji, JG
    Fickes, MG
    Fitzgerald, MA
    King, SA
    Morton, HE
    Plagge, FA
    Preskill, M
    Wagaw, SH
    Wittenberger, SJ
    Zhang, J
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (44) : 13097 - 13105
  • [46] BARTSCH RA, 1998, MOL IONIC RECOGNITIO
  • [47] Recent advances in the Baylis-Hillman reaction and applications
    Basavaiah, D
    Rao, AJ
    Satyanarayana, T
    [J]. CHEMICAL REVIEWS, 2003, 103 (03) : 811 - 891
  • [48] Catalytic asymmetric protonation of fluoro-enolic species:: access to optically active 2-fluoro-1-tetralone
    Baur, MA
    Riahi, A
    Hénin, F
    Muzart, J
    [J]. TETRAHEDRON-ASYMMETRY, 2003, 14 (18) : 2755 - 2761
  • [49] Baylis A. B., 1972, CHEM ABSTR 34174Q, V77
  • [50] Baylis A. B, 1972, German Patent, Patent No. 2155113