miRGen 2.0: a database of microRNA genomic information and regulation

被引：95

作者：

Alexiou, Panagiotis ^{[1
]}

Vergoulis, Thanasis ^{[2
,3
]}

Gleditzsch, Martin ^{[4
]}

Prekas, George ^{[3
]}

Dalamagas, Theodore ^{[2
]}

Megraw, Molly ^{[5
]}

Grosse, Ivo ^{[4
]}

Sellis, Timos ^{[2
,3
]}

Hatzigeorgiou, Artemis G. ^{[6
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Biol, GR-54006 Thessaloniki, Greece

[2] Athena Res Ctr, Inst Management Informat Syst, Athens, Greece

[3] Natl Tech Univ Athens, Knowledge & Database Syst Lab, Dept Comp Sci, Sch Elect & Comp Engn, Athens, Greece

[4] Univ Halle Wittenberg, Inst Comp Sci, Halle, Germany

[5] Duke Univ, Inst Genome Sci & Policy, Durham, NC USA

[6] Univ Penn, Philadelphia, PA 19104 USA

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

D O I：

10.1093/nar/gkp888

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3'UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims to provide comprehensive information about the position of human and mouse microRNA coding transcripts and their regulation by transcription factors, including a unique compilation of both predicted and experimentally supported data. Expression profiles of microRNAs in several tissues and cell lines, single nucleotide polymorphism locations, microRNA target prediction on protein coding genes and mapping of miRNA targets of co-regulated miRNAs on biological pathways are also integrated into the database and user interface. The miRGen database will be continuously maintained and freely available at http://www.microrna.gr/mirgen/.

引用

页码：D137 / D141

页数：5

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