Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest

被引：54

作者：

Cao, Shugeng

Norris, Andrew

Miller, James S.

Ratovoson, Fidy

Razafitsalama, Jeremi

Andriantsiferana, Rabodo

Rasamison, Vincent E.

TenDyke, Karen

Suh, Ted

Kingston, David G. I.

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Eisai Res Inst, Andover, MA 01810 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 03期

关键词：

D O I：

10.1021/np060506g

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 mu g/mL, respectively.

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页码：361 / 366

页数：6

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