Apolipoproteins and lipoprotein particles in Moroccan patients with previous myocardial infarction

被引:2
作者
Adlouni, A
El Messal, M
Ghalim, N
Saile, R
机构
[1] Fac Sci Ben Msik, Dept Biol, Lab Rech Lipoprot, Casablanca, Morocco
[2] Fac Sci Ain Chock, Lab Biochim Biol Cellulaire & Mol, Casablanca, Morocco
[3] Inst Pasteur, Biochim Lab, Casablanca, Morocco
关键词
myocardial infarction; apolipoprotein; lipoprotein particles; cholesterol; cardiovascular risk factor;
D O I
10.1007/BF02912466
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We investigated for the first time in the Moroccan population the relationship between lipoprotein particles and the progression of coronary atherosclerosis. Plasma lipid variables, including total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, apolipoproteins Al and B, Lp AI, Lp AI:AII, and Lp(a) were measured in 40 Moroccan adults who suffered a verified myocardial infarction before the age of 50 years. The results were compared with a healthy control group. Plasma total cholesterol, triglyceride, and Lp AI:AII levels of patients did not differ significantly from control subjects. Patients had lower plasma high-density lipoprotein-cholesterol (P < 0.05), apo AI (P < 0.05), and Lp Al (P < 0.001) than control subjects, suggesting that the cholesterol reverse transport system is altered in patients with previous myocardial infarction. How ever, patients had higher plasma low-density lipoprotein-cholesterol (P < 0.001), apo B (P < 0.001), and Lp(a) (P < 0.001): In all patients the best predictor of cardiovascular risk was the independent risk factor Lp(a) plasma level, and the Lp Al plasma level. In this study, the increased coronary atherosclerosis risk with elevated plasma levels of apo B and Lp(a), and with reduced Lp AI, was substantially modified by smoking habits, but not by family history of myocardial infarction.
引用
收藏
页码:247 / 252
页数:6
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