Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

被引：15

作者：

Jang, MH

Shin, MC

Koo, GS

Lee, CY

Kim, EH

Kim, CJ

机构：

[1] Kyung Hee Univ, Coll Med, Dept Physiol, Dongdaemoon Gu, Seoul 130701, South Korea

[2] Kyungwon Univ, Coll Oriental Med, Dept Physiol, Sungnam, South Korea

[3] Semyung Univ, Coll Oriental Med, Dept Meridianol, Jechon, South Korea

来源：

NEUROSCIENCE LETTERS | 2003年 / 337卷 / 03期

关键词：

acupuncture; diabetes; nitric oxide synthase; neuronal nitric oxide synthase; dorsolateral periaqueductal gray;

D O I：

10.1016/S0304-3940(02)01318-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 158

页数：4

共 20 条

[1] ENDOGENOUS PAIN CONTROL-SYSTEMS - BRAIN-STEM SPINAL PATHWAYS AND ENDORPHIN CIRCUITRY [J].