Total synthesis of 2′-O-methylmyxalamide D and (6E)-2′-O-methylmyxalamide D

被引：57

作者：

Coleman, Robert S. ^{[1
]}

Lu, Xiaoling ^{[1
]}

Modolo, Isabelle ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 13期

关键词：

D O I：

10.1021/ja070265e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hetero-bis-metalated 1,3,5-hexatrienes are employed in the linchpin coupling of synthetic fragments for the convergent construction of the central pentaene of the antifungal agent 2'-O-methylmyxalamide D and its (6E) isomer. Sequential Stille and Suzuki-Miyaura couplings interpolate the boron/tin triene into the pentaene chain. The total synthesis of O-methylmyxalamide D and its (6E) isomer was accomplished efficiently.

引用

页码：3826 / +

页数：3

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