S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase

被引：20

作者：

Drysdale, MJ

Reinhard, JF

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Combinatorial Med Chem, Stevenage SG1 2NY, Herts, England

[2] Glaxo Wellcome Inc, Res & Dev, Dept Pharmacol, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10209-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：133 / 138

页数：6

共 17 条

[11] MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE [J].