Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes

被引：63

作者：

Chen, LC ^{[1
]}

Majde, JA ^{[1
]}

Krueger, JA ^{[1
]}

机构：

[1] Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA

来源：

BRAIN RESEARCH | 2003年 / 973卷 / 02期

关键词：

NOS; nitric oxide; sleep; rapid eye movement; electroencephologram; EEG;

D O I：

10.1016/S0006-8993(03)02484-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in rapid eye movement sleep (REMS) regulation. To further investigate the role of NO in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes. REMS in nNOS KO mice was substantially lower than that of their control mice. In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：214 / 222

页数：9

共 55 条

[21] The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep [J].