A scaleable and defined system for generating neural stem cells from human embryonic stem cells

被引：87

作者：

Joannides, Alexis J.

Fiore-Heriche, Christelle

Battersby, Alysia A.

Athauda-Arachchi, Pandula

Bouhon, Isabelle A.

Williams, Lydia

Westmore, Kristine

Kemp, Paul J.

Compston, Alastair

Allen, Nicholas D.

Chandran, Siddharthan ^{[1
]}

机构：

[1] Cambridge Ctr Brain Repair, Dept Clin Neurosci, Cambridge CB2 2PY, England

[2] Univ Cardiff Wales, Sch Biosci, Cardiff, Wales

来源：

STEM CELLS | 2007年 / 25卷 / 03期

基金：

英国医学研究理事会;

关键词：

human embryonic stem cells; neural stem cells; defined conditions; fibroblast growth factor;

D O I：

10.1634/stemcells.2006-0562

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.

引用

收藏

页码：731 / 737

页数：7

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