Irreversible cell-cycle transitions are due to systems-level feedback

被引：140

作者：

Novak, Bela

Tyson, John J.

Gyorffy, Bela

Csikasz-Nagy, Attila

机构：

[1] Univ Oxford, Oxford Ctr Integrat Syst Biol, Oxford OX1 3QU, England

[2] Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA

[3] Hungarian Acad Sci, Mol Network Dynam Res Grp, H-1521 Budapest, Hungary

[4] Budapest Univ Technol & Econ, H-1521 Budapest, Hungary

[5] Univ Trent, Microsoft Res, Ctr Computat & Syst Biol, I-38100 Povo, Trento, Italy

来源：

NATURE CELL BIOLOGY | 2007年 / 9卷 / 07期

关键词：

D O I：

10.1038/ncb0707-724

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle ( or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.

引用

页码：724 / 728

页数：5

共 31 条

[1] MECHANISMS THAT HELP THE YEAST-CELL CYCLE CLOCK TICK - G2 CYCLINS TRANSCRIPTIONALLY ACTIVATE G2 CYCLINS AND REPRESS G1 CYCLINS [J].