Creation of enantioselective biocatalysts for organic chemistry by in vitro evolution

被引：313

作者：

Reetz, MT ^{[1
]}

Zonta, A

Schimossek, K

Liebeton, K

Jaeger, KE

机构：

[1] Ruhr Univ Bochum, Lehrstuhl Biol Mikroorganismen, D-44780 Bochum, Germany

[2] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1997年 / 36卷 / 24期

关键词：

asymmetric catalysis; enzyme catalysis; lipases; mutagenesis; screening methods;

D O I：

10.1002/anie.199728301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：2830 / 2832

页数：3

共 45 条

[1] Directed evolution: Creating biocatalysts for the future [J].

Arnold, FH .

CHEMICAL ENGINEERING SCIENCE, 1996, 51 (23) :5091-5102

[2] Analysis of the catalytic mechanism of a fungal lipase using computer-aided design and structural mutants [J].

Beer, HD ;

Wohlfahrt, G ;

McCarthy, JEG ;

Schomburg, D ;

Schmid, RD .

PROTEIN ENGINEERING, 1996, 9 (06) :507-517

[3]

Berrisford D.J., 1995, ANGEW CHEM, V107, P1159

[4] LIGAND-ACCELERATED CATALYSIS [J].

BERRISFORD, DJ ;

BOLM, C ;

SHARPLESS, KB .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (10) :1059-1070

[5]

BOLAND W, 1991, SYNTHESIS-STUTTGART, P1049

[6]

Cadwell R C, 1992, PCR Methods Appl, V2, P28, DOI 10.1101/gr.2.1.28

[7] TUNING THE ACTIVITY OF AN ENZYME FOR UNUSUAL ENVIRONMENTS - SEQUENTIAL RANDOM MUTAGENESIS OF SUBTILISIN-E FOR CATALYSIS IN DIMETHYLFORMAMIDE [J].

CHEN, KQ ;

ARNOLD, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) :5618-5622

[8]

Collins A.N., 1992, CHIRALITY IND COMMER

[9]

COLLINS AN, 1997, CHIRALITY IND, V2

[10] Molecular evolution of an arsenate detoxification pathway DNA shuffling [J].

Crameri, A ;

Dawes, G ;

Rodriguez, E ;

Silver, S ;

Stemmer, WPC .

NATURE BIOTECHNOLOGY, 1997, 15 (05) :436-438

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