Synergistic interaction between CCK and leptin to regulate food intake

被引:94
作者
Wang, LX
Barachina, MD
Martínez, V
Wei, JY
Taché, Y
机构
[1] Univ Calif Los Angeles, Digest Dis Res Ctr, CURE, Los Angeles, CA 90073 USA
[2] VA Greater Los Angeles Healthcare Syst, Dept Med, Div Digest Dis, Los Angeles, CA 90073 USA
[3] VA Greater Los Angeles Healthcare Syst, Brain Res Inst, Los Angeles, CA 90073 USA
[4] Univ Valencia, Sch Med, Dept Pharmacol, Valencia, Spain
[5] CEU San Pablo, Sch Vet, Dept Physiol, Valencia 46113, Spain
关键词
cholecystokinin; feeding behavior; vagus; satiety; body weight; gastric emptying; nucleus tractus solitarius; paraventricular nucleus of the hypothalamus;
D O I
10.1016/S0167-0115(00)00153-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leptin administered (either intracerebroventricularly, icv, or intraperitoneally, ip) acts in synergy with CCK to suppress food intake and body weight in lean mice or rats. The potentiating effect induced by the co-injection of ip CCK and leptin to inhibit food consumption in mice is mediated by the CCK-A receptor and capsaicin sensitive afferents. In vitro, studies: in rats showed that a subset of gastric vagal afferent fibers responded to leptin injected directly into the gastric artery only after a prior intra-arterial CCK injection. Moreover, the tonic activity of gastric-related neurons in the nucleus tractus solitarius (NTS) increased when leptin was delivered into the gastric chamber of an in vitro stomach-brainstem preparation. CCK co-injected with leptin potentiated Fos expression selectively in the area postrema, NTS and paraventricular nucleus of the hypothalamus (PVN), which points to the PVN as part of the afferent and efferent limbs of the circuitry involved in the synergistic interaction between leptin and CCK. The dampening of CCK or leptin inhibitory action on ingestive behavior when either factor is not present or their receptors are non functional supports the notion that such leptin-CCK interaction may have a physiological relevance. These observations provide a mean through which leptin and CCK integrate short- and mid-term meal-related input signals into long-term control of energy balance. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:79 / 85
页数:7
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