In vitro activities of telithromycin and 10 oral agents against aerobic and anaerobic pathogens isolated from antral puncture specimens from patients with sinusitis

A study of the comparative in vitro activity of telithromycin, a new ketolide, against 155 aerobic and 171 anaerobic antral sinus puncture isolates showed it to be active against a broad range of sinus pathogens. All pneumococci, including erythromycin-resistant strains, were susceptible to telithromycin at :less than or equal to0.5 mug/ml; all Haemophilus influenzae and Eikenella corrodens strains were inhibited by less than or equal to4 mug of telithromycin/ml; all Moraxella spp. and beta-lactamase-producing Prevotella species strains were inhibited by less than or equal to0.25 and 0.5 mug of telithromycin/ml, respectively. Among all anaerobes tested, 94% (160 of 171 strains) were susceptible to less than or equal to4 mug of telithromycin/ml; however, 8 of 17 (47%) Fusobacterium strains, 2 Veillonella strains, and 1 Peptostreptococcus micros strain required >4 mug of telithromycin/ml for inhibition. Telithromycin may offer a therapeutic alternative for sinus infections, including those due to erythromycin-resistant pneumococci.