Motoring along with the bacterial RecA protein

被引：196

作者：

Cox, Michael M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2099

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recombinases of the RecA family are often viewed only as DNA-pairing proteins-they bind to one DNA segment, align it with homologous sequences in another DNA segment, promote an exchange of DNA strands and then dissociate. To a first approximation, this description seems to fit the eukaryotic (Rad51 and Dmc1) and archaeal (RadA) RecA homologues. However, the bacterial RecA protein does much more, coupling ATP hydrolysis with DNA-strand exchange in a manner that greatly expands its repertoire of activities. This article explores the protein activities and experimental results that have identified RecA as a motor protein.

引用

页码：127 / 138

页数：12

共 109 条

[41] Direct observation of individual RecA filaments assembling on single DNA molecules [J].

Galletto, Roberto ;

Amitani, Ichiro ;

Baskin, Ronald J. ;

Kowalczykowski, Stephen C. .

NATURE, 2006, 443 (7113) :875-878

[42] The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase [J].

Gomis-Rüth, FX ;

Moncalián, G ;

Pérez-Luque, R ;

González, A ;

Cabezón, E ;

de la Cruz, F ;

Coll, M .

NATURE, 2001, 409 (6820) :637-641

[43] Rapid exchange of A:T base pairs is essential for recognition of DNA homology by human Rad51 recombination protein [J].

Gupta, RC ;

Folta-Stogniew, E ;

O'Malley, S ;

Takahashi, M ;

Radding, CM .

MOLECULAR CELL, 1999, 4 (05) :705-714

[44] A DNA pairing-enhanced conformation of bacterial RecA proteins [J].

Haruta, N ;

Yu, XN ;

Yang, SX ;

Egelman, EH ;

Cox, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (52) :52710-52723

[45] Bypass of heterology during strand transfer by Saccharomyces cerevisiae Rad51 protein [J].

Holmes, VF ;

Benjamin, KR ;

Crisona, NJ ;

Cozzarelli, NR .

NUCLEIC ACIDS RESEARCH, 2001, 29 (24) :5052-5057

[46] ROLE OF RECA PROTEIN SPIRAL FILAMENTS IN GENETIC-RECOMBINATION [J].

HOWARDFLANDERS, P ;

WEST, SC ;

STASIAK, A .

NATURE, 1984, 309 (5965) :215-220

[47]

JAIN SK, 1994, J BIOL CHEM, V269, P20653

[48] Real-time observation of RecA filament dynamics with single monomer resolution [J].

Joo, Chirlmin ;

McKinney, Sean A. ;

Nakamura, Muneaki ;

Rasnik, Ivan ;

Myong, Sua ;

Ha, Taekjip .

CELL, 2006, 126 (03) :515-527

[49]

KIM JI, 1992, J BIOL CHEM, V267, P16444

[50]

KIM JI, 1992, J BIOL CHEM, V267, P16438

← 1 2 3 4 5 6 7 8 9 10 →