Regulation of B cell development by Notch/RBP-J signaling

被引：36

作者：

Tanigaki, K ^{[1
]}

Kuroda, K ^{[1
]}

Han, H ^{[1
]}

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 02期

关键词：

conditional knockout; Fo B cells; MZ B cells; staphylococcal infection;

D O I：

10.1016/S1044-5323(03)00008-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

RBP-J is an essential signal mediator of all four Notches in nuclei. Loss-of-function analyses clearly show the crucial roles of RBP-J in commitment of T cells versus B cells as well as MZ B cells versus Fo B cells. Such Notch/RBP-J regulation of dichotomic differentiation steps in lymphocyte is reminiscent of the development of sensory organ precursors (SOPs) in Drosophila. Studies on RBP-J conditional knockout mice that have lost MZ B cells without affecting Fo B cell functions have shown that MZ B cells play pivotal roles in immune responses to blood-borne bacteria. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：113 / 119

页数：7

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