Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guerin vaccination

被引：43

作者：

Brown, RM

Cruz, O

Brennan, M

Gennaro, ML

Schlesinger, L

Skeiky, YAW

Hoft, DF

机构：

[1] St Louis Univ, Hlth Sci Ctr, Dept Internal Med,Vaccine & Treatment Evaluat Uni, Div Infect Dis & Immunol, St Louis, MO 63110 USA

[2] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA

[3] Publ Hlth Res Inst City New York Inc, New York, NY 10016 USA

[4] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[5] Univ Iowa, Dept Med, Div Infect Dis, Iowa City, IA 52242 USA

[6] Univ Iowa, Program Immunol, Iowa City, IA 52242 USA

[7] Corixa, Seattle, WA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 187卷 / 03期

关键词：

D O I：

10.1086/368096

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of 17 recombinant mycobacterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody responses induced by bacille Calmette-Guerin (BCG) vaccination and active tuberculosis infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum immunoglobulin G responses were significantly increased in both BCG-vaccinated patients and patients with active tuberculosis (P < .05), and oral BCG vaccination also induced significant increases in LAM-reactive secretory immunoglobulin A (P < .05). LAM-reactive antibody assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer attenuated mycobacterial vaccines.

引用

页码：513 / 517

页数：5

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