Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats

被引：19

作者：

File, SE

Hartley, DE

Alom, N

Rattray, M

机构：

[1] Kings Coll London, Ctr Res Neurosci, Psychopharmacol Res Unit, London SE1 1UL, England

[2] Kings Coll London, Ctr Res Neurosci, Biochem Neuropharmacol Grp, London SE1 1UL, England

来源：

NEUROSCIENCE LETTERS | 2003年 / 338卷 / 02期

关键词：

neurotrophin; phytoestrogen; oestrogen-beta receptor;

D O I：

10.1016/S0304-3940(02)01391-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult male hooded Lister rats were either fed a diet containing 150 mug/g soya phytoestrogens or a soya-free diet for 18 days. This concentration of phytoestrogens should have been sufficient to occupy the oestrogen-beta, but not the oestrogen-alpha, receptors. Using in situ hybridisation, significant reductions were found in brain-derived neurotrophic factor (BDNF) mRNA expression in the CA3 and CA4 region of the hippocampus and in the cerebral cortex in the rats fed the diet containing phytoestrogens, compared with those on the soya-free diet. No changes in glutamic acid decarboxylase-67 or glial fibrillary acidic protein mRNA were found. This suggests a role for oestrogen-beta receptors in regulating BDNF mRNA expression. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：135 / 138

页数：4

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