T2-Weighted 3D fMRI Using S2-SSFP at 7 Tesla

被引:29
作者
Barth, Markus [1 ,2 ]
Meyer, Heiko [3 ]
Kannengiesser, Stephan A. R. [3 ]
Polimeni, Jonathan R. [4 ,5 ]
Wald, Lawrence L. [4 ,5 ]
Norris, David G. [1 ,2 ]
机构
[1] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
[2] Univ Duisburg Essen, EL Hahn Inst Magnet Resonance Imaging, Essen, Germany
[3] Siemens Healthcare, MR Applicat Dev, Erlangen, Germany
[4] Massachusetts Gen Hosp, Dept Radiol, AA Martinos Ctr, Charlestown, MA USA
[5] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
基金
美国国家卫生研究院;
关键词
BOLD; 7; tesla; brain; neuroimaging; steady-state free procession; STATE FREE PRECESSION; HUMAN VISUAL-CORTEX; SPIN-ECHO FMRI; HUMAN BRAIN; FUNCTIONAL MRI; STEADY-STATE; NOISE CHARACTERISTICS; PARALLEL MRI; HIGH-FIELD; BOLD FMRI;
D O I
10.1002/mrm.22283
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In this study, the sensitivity of the S-2-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S-2-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S-2-signal but was slightly lower for the S-2-signal (6.74 +/- 0.32 for the TR = 15 ms protocol and 7.51 +/- 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 +/- 1.44 and 8.05 +/- 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% +/- 0.18%) compared to the TR = 15 ms S-2-SSFP protocol (2.75% +/- 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% +/- 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S-2 signal. In conclusion, whole-brain T-2-weighted functional MRI with negligible image distortion at 7 T is feasible using the S-2-SSFP sequence and partially parallel imaging. Magn Reson Med 63:1015-1020, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:1015 / 1020
页数:6
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