The Stunned β Cell: A Brief History

被引：164

作者：

Ferrannini, Ele ^{[1
]}

机构：

[1] Univ Pisa, Sch Med, Dept Internal Med, I-56100 Pisa, Italy

来源：

CELL METABOLISM | 2010年 / 11卷 / 05期

关键词：

INSULIN-RESISTANCE; SECRETION; APOPTOSIS; HUMANS; ISLETS;

D O I：

10.1016/j.cmet.2010.04.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

beta cell dysfunction is sufficient to cause hyperglycemia; beta cell loss is not necessary but, if severe, can be sufficient and may be accompanied by intrinsic beta cell dysfunction. Clinical testing can differentiate beta cell capacity from beta cell glucose sensitivity but cannot ascribe either to relative changes in beta cell mass versus function. However, longitudinal and intervention studies indicate that beta cell glucose insensitivity (stunning) closely tracks with hyperglycemia and is, at least in part, reversible. Rescuing stunned beta cells is a key therapeutic target.

引用

页码：349 / 352

页数：4

共 11 条

[1]

β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[2]

β-cell function in morbidly obese subjects during free living -: Long-term effects of weight loss [J].

Camastra, S ;

Manco, M ;

Mari, A ;

Baldi, S ;

Gastaldelli, A ;

Greco, AV ;

Mingrone, G ;

Ferrannini, E .

DIABETES, 2005, 54 (08) :2382-2389

[3]

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance [J].

Cavaghan, MK ;

Ehrmann, DA ;

Polonsky, KS .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (03) :329-333

[4]

β-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes:: A new analysis [J].

Ferrannini, E ;

Gastaldelli, A ;

Miyazaki, Y ;

Matsuda, M ;

Mari, A ;

DeFronzo, RA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (01) :493-500

[5]

Insulin resistance, insulin response, and obesity as indicators of metabolic risk [J].

Ferrannini, Ele ;

Balkau, Beverley ;

Coppack, Simon W. ;

Dekker, Jacqueline M. ;

Mari, Andrea ;

Nolan, John ;

Walker, Mark ;

Natali, Andrea ;

Beck-Nielsen, Henning .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (08) :2885-2892

[6]

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes [J].

Hanley, Stephen C. ;

Austin, Emily ;

Assouline-Thomas, Beatrice ;

Kapeluto, Jordanna ;

Blaichman, Jason ;

Moosavi, Mandana ;

Petropavlovskaia, Maria ;

Rosenberg, Lawrence .

ENDOCRINOLOGY, 2010, 151 (04) :1462-1472

[7]

Nutrient control of insulin secretion in isolated normal human islets [J].

Henquin, Jean-Claude ;

Dufrane, Denis ;

Nenquin, Myriam .

DIABETES, 2006, 55 (12) :3470-3477

[8]

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin [J].

Marchetti, P ;

Del Guerra, S ;

Marselli, L ;

Lupi, R ;

Masini, M ;

Pollera, M ;

Bugliani, M ;

Boggi, U ;

Vistoli, F ;

Mosca, F ;

Del Prato, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (11) :5535-5541

[9]

Functional Assessment of Pancreatic β-Cell Area in Humans [J].

Meier, Juris J. ;

Menge, Bjoern A. ;

Breuer, Thomas G. K. ;

Mueller, Christophe A. ;

Tannapfel, Andrea ;

Uhl, Waldemar ;

Schmidt, Wolfgang E. ;

Schrader, Henning .

DIABETES, 2009, 58 (07) :1595-1603

[10]

Pancreatic β-cell mass in European subjects with type 2 diabetes [J].

Rahier, J. ;

Guiot, Y. ;

Goebbels, R. M. ;

Sempoux, C. ;

Henquin, J. C. .

DIABETES OBESITY & METABOLISM, 2008, 10 :32-42

← 1 2 →