Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia

被引:56
作者
Roblin, PM
Hammerschlag, MR
机构
[1] SUNY Hlth Sci Ctr, Dept Pediat, Brooklyn, NY 11203 USA
[2] SUNY Hlth Sci Ctr, Dept Med, Brooklyn, NY 11203 USA
关键词
D O I
10.1128/AAC.42.1.194
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chlamydia pneumoniae was eradicated from the nasopharynges of 26 of 33 (78.8%) evaluable children and adults with community-acquired pneumonia who were treated with azithromycin. We tested 55 isolates of C. pneumoniae obtained from 46 of these patients against azithromycin. The MIC at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of strains tested were killed of azithromycin for these isolates were both 0.5 mu g/ml. Seven patients remained culture positive after treatment. The MICs of azithromycin for isolates from two patients increased fourfold after therapy. However, all the patients with persistent infection improved clinically. Further studies of treatment of C. pneumoniae infection, utilizing culture, are needed both to assess efficacy and to monitor for the possible development of antibiotic resistance.
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收藏
页码:194 / 196
页数:3
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共 13 条
  • [1] A COMPARATIVE SAFETY AND EFFICACY STUDY OF CLARITHROMYCIN AND ERYTHROMYCIN STEARATE IN COMMUNITY-ACQUIRED PNEUMONIA
    ANDERSON, G
    ESMONDE, TS
    COLES, S
    MACKLIN, J
    CARNEGIE, C
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 27 : 117 - 124
  • [2] MYCOPLASMA-PNEUMONIAE AND CHLAMYDIA-PNEUMONIAE IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIA - COMPARATIVE EFFICACY AND SAFETY OF CLARITHROMYCIN VS ERYTHROMYCIN ETHYLSUCCINATE
    BLOCK, S
    HEDRICK, J
    HAMMERSCHLAG, MR
    CASSELL, GH
    CRAFT, JC
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1995, 14 (06) : 471 - 477
  • [3] TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA - A MULTICENTER, DOUBLE-BLIND, RANDOMIZED STUDY COMPARING CLARITHROMYCIN WITH ERYTHROMYCIN
    CHIEN, SM
    PICHOTTA, P
    SIEPMAN, N
    CHAN, CK
    [J]. CHEST, 1993, 103 (03) : 697 - 701
  • [4] A NEW RESPIRATORY-TRACT PATHOGEN - CHLAMYDIA-PNEUMONIAE STRAIN TWAR
    GRAYSTON, JT
    CAMPBELL, LA
    KUO, CC
    MORDHORST, CH
    SAIKKU, P
    THOM, DH
    WANG, SP
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (04) : 618 - 625
  • [5] INVITRO ACTIVITIES OF AZITHROMYCIN, CLARITHROMYCIN, L-OFLOXACIN, AND OTHER ANTIBIOTICS AGAINST CHLAMYDIA-PNEUMONIAE
    HAMMERSCHLAG, MR
    QUMEI, KK
    ROBLIN, PM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (07) : 1573 - 1574
  • [6] PERSISTENT INFECTION WITH CHLAMYDIA-PNEUMONIAE FOLLOWING ACUTE RESPIRATORY ILLNESS
    HAMMERSCHLAG, MR
    CHIRGWIN, K
    ROBLIN, PM
    GELLING, M
    DUMORNAY, W
    MANDEL, L
    SMITH, P
    SCHACHTER, J
    [J]. CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) : 178 - 182
  • [7] PARTIAL CHARACTERIZATION OF CHLAMYDIA-TRACHOMATIS ISOLATES RESISTANT TO MULTIPLE ANTIBIOTICS
    JONES, RB
    VANDERPOL, B
    MARTIN, DH
    SHEPARD, MK
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (06) : 1309 - 1315
  • [8] RELATIVE RESISTANCE TO ERYTHROMYCIN IN CHLAMYDIA-TRACHOMATIS
    MOURAD, A
    SWEET, RL
    SUGG, N
    SCHACHTER, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (05) : 696 - 698
  • [9] USE OF HEP-2 CELLS FOR IMPROVED ISOLATION AND PASSAGE OF CHLAMYDIA-PNEUMONIAE
    ROBLIN, PM
    DUMORNAY, W
    HAMMERSCHLAG, MR
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (08) : 1968 - 1971
  • [10] SUSCEPTIBILITIES TO CLARITHROMYCIN AND ERYTHROMYCIN OF ISOLATES OF CHLAMYDIA-PNEUMONIAE FROM CHILDREN WITH PNEUMONIA
    ROBLIN, PM
    MONTALBAN, G
    HAMMERSCHLAG, MR
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) : 1588 - 1589