Synthesis of chirally pure ornithine based PNA analogues

被引：28

作者：

van der Laan, AC

van Amsterdam, I

Tesser, GI

van Boom, JH

Kuyl-Yeheskiely, E

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

[2] Catholic Univ Nijmegen, Organ Chem Lab, NL-6525 ED Nijmegen, Netherlands

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 1-3期

关键词：

D O I：

10.1080/07328319808005171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A stereoselective synthesis of a chiral PNA analogue containing an ornithine based backbone is described. In this approach each elongation cycle consists of two individual coupling steps: i.e. extension of the free delta-amino function in the growing chain by a TOPPipU mediated coupling with Fmoc-Om(Boc)-OH, and subsequent acylation of a free alpha-amine with thymin-1-ylacetic acid. Thyminyl decamers were prepared following this strategy and hybridization experiments indicated that they formed stable complexes with cRNA.

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页码：219 / 231

页数：13

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