The proteasorne and MHC class I antigen processing

被引：140

作者：

Kloetzel, PM ^{[1
]}

机构：

[1] Humboldt Univ, Inst Biochem, Charite, Fak Med, D-10117 Berlin, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1695卷 / 1-3期

关键词：

proteasome; immune response; antigen presentation; MHC-complex; intereferon-gamma; interferon; antigen processing;

D O I：

10.1016/j.bbamcr.2004.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By generating peptides from intracellular antigens, which are then presented to T cells, the ubiquitin/26S proteasome system plays a central role in the cellular immune response. Under the control of interferon-gamma the proteolytic properties of the proteasome are adapted to the requirements of the immune system. Interferon-gamma induces the formation of immunoproteasomes and the synthesis of the proteasome activator PA28. Both alter the proteolytic properties of the proteasome complex and enhance proteasomal function in antigen presentation. Thus. a combination of several of regulatory events tunes the proteasome system for maximal efficiency in the generation of MHC class I antigens. (C) 2004 Published by Elsevier B.V.

引用

页码：225 / 233

页数：9

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