Antimicrobial susceptibility testing of dermatophytes - Comparison of the agar macrodilution and broth microdilution tests

被引:26
作者
Niewerth, M
Splanemann, V
Korting, HC
Ring, J
Abeck, D
机构
[1] Tech Univ Munich, Dermatol Klin & Poliklin, D-80802 Munich, Germany
[2] Univ Hamburg, Krankenhaus Eppendorf, Hautklin, D-2000 Hamburg, Germany
[3] Univ Munich, Dermatol Klin & Poliklin, D-8000 Munich, Germany
关键词
dermatophytes; agar macrodilution test; broth microdilution test; griseofulvin; terbinafine; ciclopiroxolamine; itraconazole; sertaconazole;
D O I
10.1159/000007087
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test. Antimycotics compared were griseofulvin, itraconazole, sertaconazole, terbinafine and ciclopiroxolamine. A comparison of the minimum inhibitory concentrations (MIC) clearly showed differences between the two test methods applied. For all 5 antimycotics, MIC data were three- to seventyfold lower in the microdilution test system. These differences, depending on the test method, have to be taken into account when comparing MIC data in the literature or when relating the in vitro data to the tissue concentrations determined in vivo.
引用
收藏
页码:31 / 35
页数:5
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