Rho GTPase-activating proteins in cell regulation

被引：478

作者：

Moon, SY ^{[1
]}

Zheng, Y ^{[1
]}

机构：

[1] Childrens Hosp Res Fdn, Div Expt Hematol, Cincinnati, OH 45229 USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(02)00004-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho family small GTPases serve as molecular switches involved in the regulation of diverse cellular functions including various cytoskeleton-related events and gene transcription. The Rho GTPase-activating proteins (Rho-GAPs) are one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions. Recent studies have implicated them as specific negative regulators of Rho protein signalling pathways and provided insight into how the RhoGAP-catalysed GTPase-activating reaction might proceed. Progress has also been made in understanding how various intracellular signals might converge on or diverge from RhoGAPs leading to their tight regulation or GAP-independent function.

引用

页码：13 / 22

页数：10

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