The genetics of Graves' disease

被引：50

作者：

Gough, SCL

机构：

[1] Birmingham Heartlands Hosp, Div Med Sci, Dept Med, Birmingham B9 5SS, W Midlands, England

[2] Univ Birmingham, Div Med Sci, Birmingham, W Midlands, England

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 02期

关键词：

D O I：

10.1016/S0889-8529(05)70130-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Population-based case control and family-based candidate gene studies have identified an important role in the development of Graves' disease for the human leukocyte antigen region on chromosome 6p21 and the cytotoxic T-lymphocyte-associated antigen 4 gene region on chromosome 2q33. Genome-wide searches also have revealed three chromosomal regions of linkage to Graves' disease, including chromosome 14q31 (GD-1), chromosome 20q11.2 (GD-2), and the X chromosome at Xq21,33-22 (GD-3), harboring a number of novel candidate genes for Graves' disease that have yet to be tested in further data sets. As more detailed genetic maps emerge, with locations of more candidate genes, the identification of all susceptibility loci for Craves' disease becomes a realistic goal.

引用

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页码：255 / +

页数：14

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