The genetics of Graves' disease

被引:50
作者
Gough, SCL
机构
[1] Birmingham Heartlands Hosp, Div Med Sci, Dept Med, Birmingham B9 5SS, W Midlands, England
[2] Univ Birmingham, Div Med Sci, Birmingham, W Midlands, England
关键词
D O I
10.1016/S0889-8529(05)70130-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Population-based case control and family-based candidate gene studies have identified an important role in the development of Graves' disease for the human leukocyte antigen region on chromosome 6p21 and the cytotoxic T-lymphocyte-associated antigen 4 gene region on chromosome 2q33. Genome-wide searches also have revealed three chromosomal regions of linkage to Graves' disease, including chromosome 14q31 (GD-1), chromosome 20q11.2 (GD-2), and the X chromosome at Xq21,33-22 (GD-3), harboring a number of novel candidate genes for Graves' disease that have yet to be tested in further data sets. As more detailed genetic maps emerge, with locations of more candidate genes, the identification of all susceptibility loci for Craves' disease becomes a realistic goal.
引用
收藏
页码:255 / +
页数:14
相关论文
共 54 条
[11]   Lack of an independent association between the human leukocyte antigen allele DQA1*0501 and Graves' disease [J].
Cuddihy, RM ;
Bahn, RS .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (02) :847-849
[12]   A POLYMORPHISM IN THE EXTRACELLULAR DOMAIN OF THE THYROTROPIN RECEPTOR IS HIGHLY ASSOCIATED WITH AUTOIMMUNE THYROID-DISEASE IN FEMALES [J].
CUDDIHY, RM ;
DUTTON, CM ;
BAHN, RS .
THYROID, 1995, 5 (02) :89-95
[13]   Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis [J].
Damotte, D ;
Colomb, E ;
Cailleau, C ;
Brousse, N ;
Charreire, J ;
Carnaud, C .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (11) :2854-2862
[14]   Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease [J].
Donner, H ;
Braun, J ;
Seidl, C ;
Rau, H ;
Finke, R ;
Ventz, M ;
Walfish, PG ;
Usadel, KH ;
Badenhoop, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (12) :4130-4132
[15]   CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus [J].
Donner, H ;
Rau, H ;
Walfish, PG ;
Braun, J ;
Siegmund, T ;
Finke, R ;
Herwig, J ;
Usadel, KH ;
Badenhoop, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (01) :143-146
[16]   The interleukin-1 receptor antagonist gene shows no allelic association with three autoimmune diseases [J].
Heward, J ;
Allahabadia, A ;
Gordon, C ;
Sheppard, MC ;
Barnett, AH ;
Franklyn, JA ;
Gough, SCL .
THYROID, 1999, 9 (06) :627-628
[17]   Genetic susceptibility to the development of autoimmune disease [J].
Heward, J ;
Gough, SCL .
CLINICAL SCIENCE, 1997, 93 (06) :479-491
[18]   Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*O2-DQA1*0501 [J].
Heward, JM ;
Allahabadia, A ;
Sheppard, MC ;
Barnett, AH ;
Franklyn, JA ;
Gough, SCL .
CLINICAL ENDOCRINOLOGY, 1999, 51 (01) :115-118
[19]   The development of Graves' disease and the CTLA-4 gene on chromosome 2q33 [J].
Heward, JM ;
Allahabadia, A ;
Armitage, M ;
Hattersley, A ;
Dodson, PM ;
MacLeod, K ;
Carr-Smith, J ;
Daykin, J ;
Daly, A ;
Sheppard, MC ;
Holder, RL ;
Barnett, AH ;
Franklyn, JA ;
Gough, SCL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (07) :2398-2401
[20]   Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: Replication using a population case control and family-based study [J].
Heward, JM ;
Allahabadia, A ;
Daykin, J ;
Carr-Smith, J ;
Daly, A ;
Armitage, M ;
Dodson, PM ;
Sheppard, MC ;
Barnett, AH ;
Franklyn, JA ;
Gough, SCL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (10) :3394-3397