共 54 条
The genetics of Graves' disease
被引:50
作者:

Gough, SCL
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机构: Birmingham Heartlands Hosp, Div Med Sci, Dept Med, Birmingham B9 5SS, W Midlands, England
机构:
[1] Birmingham Heartlands Hosp, Div Med Sci, Dept Med, Birmingham B9 5SS, W Midlands, England
[2] Univ Birmingham, Div Med Sci, Birmingham, W Midlands, England
关键词:
D O I:
10.1016/S0889-8529(05)70130-4
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Population-based case control and family-based candidate gene studies have identified an important role in the development of Graves' disease for the human leukocyte antigen region on chromosome 6p21 and the cytotoxic T-lymphocyte-associated antigen 4 gene region on chromosome 2q33. Genome-wide searches also have revealed three chromosomal regions of linkage to Graves' disease, including chromosome 14q31 (GD-1), chromosome 20q11.2 (GD-2), and the X chromosome at Xq21,33-22 (GD-3), harboring a number of novel candidate genes for Graves' disease that have yet to be tested in further data sets. As more detailed genetic maps emerge, with locations of more candidate genes, the identification of all susceptibility loci for Craves' disease becomes a realistic goal.
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页数:14
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h-index: 0
机构: Univ Birmingham, Dept Med, Birmingham Heartlands Hosp, Birmingham B9 5SS, W Midlands, England

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h-index: 0
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h-index: 0
机构: Univ Birmingham, Dept Med, Birmingham Heartlands Hosp, Birmingham B9 5SS, W Midlands, England

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机构: Univ Birmingham, Dept Med, Birmingham Heartlands Hosp, Birmingham B9 5SS, W Midlands, England
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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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h-index: 0
机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

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机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

Barnett, AH
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机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

Franklyn, JA
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机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England

Gough, SCL
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机构: Univ Birmingham, Birmingham Heartlands Hosp, Dept Med, Birmingham B9 5SS, W Midlands, England